Recombinant Human IGF1 LR3 Protein

Recombinant Human IGF1 LR3

BMEM Bio’s Recombinant Human IGF1 LR3 is a premier animal-origin free (AOF) analog of human IGF1. It is a highly stable, bio-available growth factor that drives superior proliferation at significantly lower concentrations than recombinant insulin or wild-type IGF1.

Product Summary:

·       Size: 9.1 kDa

·       Form: Tag-less protein

·       Purity: 95% by SDS-PAGE quantitative densitometry

·       Endotoxin: <0.5 EU/ug

·       Expression System: E.coli

·       Format: 1mg lyophilized

·       Resuspension Buffer: sterile water at >50 ug/mL

·       Storage: Short-term at -20ºC and long term at -80ºC.

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Key Features

Extended Half-Life: In a competitive binding assay, IGF1 LR3 showed equal affinity for the insulin receptor but showed negligible binding to Insulin-like Growth Factor Binding Proteins (IGFBPs)¹ , extending its biological half-life  when compared to wild-type IGF1.

Higher Potency: Significantly more potent than recombinant Insulin, requiring lower concentrations in cell culture medium.

Animal-Origin Free (AOF): Produced in an AOF environment for research use only.

Purity: Achieves >95% purity via SDS-PAGE quantitative densitometry with endotoxin levels below 1 EU/ug.

References:
¹ Liu, M., Xiao, R., Li, X., Zhao, Y., & Huang, J. (2025). A comprehensive review of recombinant technology in the food industry: Exploring expression systems, application, and future challenges. Comprehensive Reviews in Food Science and Food Safety, 24, e70078. https://doi.org/10.1111/1541-4337.70078